Migraine Solutions

The following article concluded: a fixed combination of indomethacin 25 mg, prochlorperazine dimaleate 4 mg, and caffeine 75 mg is significantly more effective than sumatriptan in the acute treatment of migraine attacks versus sumatriptan 25 mg, both rectal suppositories. It is notable that the combination is also less expensive than sumatriptan per unit dose.

Headache. 2003 Sep;43(8):835-44

The following article concluded: oral therapy with a combination of LAS (equivalent to 900 mg ASA) and metoclopramide 10 mg was superior to placebo with therapeutic gains of 30% and 31% for the first treated attack, and was comparable to 100 mg sumatriptan. This highlights the effectiveness of combined oral lysine acetyl salicylate and metoclopramide (Migpriv) in the treatment of migraine attacks.

Funct Neurol. 2000;15 Suppl 3:196-201